Shohan: The therapeutic efficacy of quercetin in combination with antiviral drugs in hospitalized COVID-19 patients: A randomized controlled trial

Shohan, 60 patient quercetin late treatment RCT: 86% lower mortality [p=0.24] and 32% improved recovery [p=0.04] https://c19p.org/shohan

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The therapeutic efficacy of quercetin in combination with antiviral drugs in hospitalized COVID-19 patients: A randomized controlled trial

Shohan et al., European Journal of Pharmacology, doi:10.1016/j.ejphar.2021.1746158

2 Dec 2021 Source PDF Share Tweet

Small RCT with 60 severe hospitalized patients in Iran, 30 treated with quercetin, showing shorter time until discharge. All patients received remdesivir or favipiravir, and vitamin C, vitamin D, famotidine, zinc, dexamethasone, and magnesium (depending on serum levels). Quercetin 1000mg daily for 7 days. IRCT20200419047128N2.

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risk of death, 85.7% lower, RR 0.14, p = 0.24, treatment 0 of 30 (0.0%), control 3 of 30 (10.0%), NNT 10.0, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).

risk of ICU admission, 40.0% lower, RR 0.60, p = 0.71, treatment 3 of 30 (10.0%), control 5 of 30 (16.7%), NNT 15.

days from end of intervention to discharge, 32.4% lower, relative time 0.68, p = 0.04, treatment 30, control 30.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Shohan et al., 2 Dec 2021, Randomized Controlled Trial, Iran, peer-reviewed, mean age 50.9 (treatment) 52.7 (control), 8 authors, average treatment delay 7.8 days.

Contact: akhodadadi2@gmail.com, akhodadadi@ajums.ac.ir.

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