Onal: Treatment of COVID-19 patients with quercetin: a prospective, single center, randomized, controlled trial

Onal, 429 patient quercetin late treatment RCT: 94% lower ICU admission [p=0.39] and 78% higher hospital discharge [p=0.1] https://c19p.org/onal

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Treatment of COVID-19 patients with quercetin: a prospective, single center, randomized, controlled trial

Onal et al., Turk. J. Biol., 45:518-529 (date from earlier preprint), NCT04377789 (history)

19 Jan 2021 Source PDF Share Tweet

RCT 447 moderate-to-severe hospitalized patients in Turkey, 52 treated with quercetin, bromelain, and vitamin C, showing no statistically significant difference in clinical outcomes. NCT04377789 (history).

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risk of death, 29.3% higher, RR 1.29, p = 0.57, treatment 1 of 49 (2.0%), control 6 of 380 (1.6%).

risk of ICU admission, 94.0% lower, RR 0.06, p = 0.39, treatment 0 of 49 (0.0%), control 14 of 380 (3.7%), NNT 27, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).

risk of no hospital discharge, 77.8% lower, RR 0.22, p = 0.10, treatment 1 of 49 (2.0%), control 35 of 380 (9.2%), NNT 14.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Onal et al., 19 Jan 2021, Randomized Controlled Trial, Turkey, peer-reviewed, 10 authors, this trial uses multiple treatments in the treatment arm (combined with bromelain and vitamin C) - results of individual treatments may vary, trial NCT04377789 (history).

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