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00.250.50.7511.251.51.752+Di Pierro (RCT)86%0.14 [0.01-2.72]death0/763/76Improvement, RR [CI]TreatmentControlDi Pierro (RCT)67%0.33 [0.01-7.74]death0/211/21Tau​2 = 0.00; I​2 = 0.0%Early treatment79%0.21 [0.02-1.82]0/974/9779% improvementArslan (RCT)92%0.08 [0.01-0.79]cases1/719/42CT​1Improvement, RR [CI]TreatmentControlTau​2 = 0.00; I​2 = 0.0%PrEP92%0.08 [0.01-0.79]1/719/4292% improvementAll studies87%0.13 [0.03-0.57]1/16813/13987% improvement3 quercetin COVID-19 studiesc19quercetin.com 7/24/211 CT: study uses combined treatmentTau​2 = 0.00; I​2 = 0.0%; Z = 2.72 (p = 0.0033)Effect extraction pre-specifiedLower RiskIncreased Risk
6/24
Early Di Pierro et al., International Journal of General Medicine, doi:10.2147/IJGM.S318949 (Peer Reviewed) death, ↓66.7%, p=1.00 Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial
Details   RCT 42 outpatients in Pakistan, 21 treated with quercetin phytosome, showing faster viral clearance and lower symptom severity with treatment.
6/8
Early Di Pierro et al., International Journal of General Medicine, doi:10.2147/IJGM.S318720 (Peer Reviewed) death, ↓85.7%, p=0.25 Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study
Details   RCT 152 outpatients in Pakistan, 76 treated with quercetin phytosome, showing lower mortality, ICU admission, and hospitalization with treatment.
11/16
PrEP Arslan et al., SSRN, doi:10.2139/ssrn.3682517 (Preprint) cases, ↓91.7%, p=0.03 Synergistic Effect of Quercetin and Vitamin C Against COVID-19: Is a Possible Guard for Front Liners
Details   Small prophylaxis RCT with 113 patients showing fewer cases with quercetin+vitamin C prophylaxis. NCT04377789.
10/9
Review Derosa et al., Phytotherapy Research, doi:10.1002/ptr.6887 (Review) (Peer Reviewed) review A role for quercetin in coronavirus disease 2019 (COVID-19)
Details   Review noting that quercetin has a theoretical, but significant, capability to interfere with SARS‐CoV‐2 replication, with results showing this to be the fifth best compound out of 18 candidates.
6/19
Review Biancatelli et al., Frontiers in Immunology, doi:10.3389/fimmu.2020.01451 (Review) (Peer Reviewed) review Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)
Details   Review of the evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients.
Please send us corrections, updates, or comments. Vaccines and treatments are both extremely valuable and complementary. All practical, effective, and safe means should be used. Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. Treatment protocols for physicians are available from the FLCCC.
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