Quercetin for COVID-19: real-time analysis of all 3 studies

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6/24	Early	Di Pierro et al., International Journal of General Medicine, doi:10.2147/IJGM.S318949 (Peer Reviewed)	death, ↓66.7%, p=1.00	Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial
	Details RCT 42 outpatients in Pakistan, 21 treated with quercetin phytosome, showing faster viral clearance and lower symptom severity with treatment.
6/24	Details Source PDF Early treatment study Early treatment study
	Di Pierro et al., International Journal of General Medicine, doi:10.2147/IJGM.S318949 (Peer Reviewed)
	Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial
	RCT 42 outpatients in Pakistan, 21 treated with quercetin phytosome, showing faster viral clearance and lower symptom severity with treatment. risk of death, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 21 (0.0%), control 1 of 21 (4.8%), continuity correction due to zero event. risk of ICU admission, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 21 (0.0%), control 1 of 21 (4.8%), continuity correction due to zero event. risk of hospitalization, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 21 (0.0%), control 1 of 21 (4.8%), continuity correction due to zero event. risk of no virological cure, 73.7% lower, RR 0.26, p < 0.001, treatment 5 of 21 (23.8%), control 19 of 21 (90.5%), day 7. risk of no virological cure, 88.9% lower, RR 0.11, p = 0.11, treatment 0 of 21 (0.0%), control 4 of 21 (19.0%), continuity correction due to zero event, day 14. Di Pierro et al., 6/24/2021, Randomized Controlled Trial, Pakistan, Middle East, peer-reviewed, 12 authors.
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6/8	Early	Di Pierro et al., International Journal of General Medicine, doi:10.2147/IJGM.S318720 (Peer Reviewed)	death, ↓85.7%, p=0.25	Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study
	Details RCT 152 outpatients in Pakistan, 76 treated with quercetin phytosome, showing lower mortality, ICU admission, and hospitalization with treatment.
6/8	Details Source PDF Early treatment study Early treatment study
	Di Pierro et al., International Journal of General Medicine, doi:10.2147/IJGM.S318720 (Peer Reviewed)
	Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study
	RCT 152 outpatients in Pakistan, 76 treated with quercetin phytosome, showing lower mortality, ICU admission, and hospitalization with treatment. risk of death, 85.7% lower, RR 0.14, p = 0.25, treatment 0 of 76 (0.0%), control 3 of 76 (3.9%), continuity correction due to zero event. risk of ICU admission, 94.1% lower, RR 0.06, p = 0.006, treatment 0 of 76 (0.0%), control 8 of 76 (10.5%), continuity correction due to zero event. risk of hospitalization, 68.2% lower, RR 0.32, p = 0.003, treatment 7 of 76 (9.2%), control 22 of 76 (28.9%). Di Pierro et al., 6/8/2021, Randomized Controlled Trial, Pakistan, Middle East, peer-reviewed, 19 authors.
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11/16	PrEP	Arslan et al., SSRN, doi:10.2139/ssrn.3682517 (Preprint)	cases, ↓91.7%, p=0.03	Synergistic Effect of Quercetin and Vitamin C Against COVID-19: Is a Possible Guard for Front Liners
	Details Small prophylaxis RCT with 113 patients showing fewer cases with quercetin+vitamin C prophylaxis. NCT04377789.
11/16	Details Source PDF Pre-Exposure Prophylaxis study Pre-Exposure Prophylaxis study
	Arslan et al., SSRN, doi:10.2139/ssrn.3682517 (Preprint)
	Synergistic Effect of Quercetin and Vitamin C Against COVID-19: Is a Possible Guard for Front Liners
	Small prophylaxis RCT with 113 patients showing fewer cases with quercetin+vitamin C prophylaxis. NCT04377789. risk of COVID-19 case, 91.7% lower, RR 0.08, p = 0.03, treatment 1 of 71 (1.4%), control 9 of 42 (21.4%), adjusted. Arslan et al., 11/16/2020, Randomized Controlled Trial, Turkey, Europe, preprint, 7 authors, this trial uses multiple treatments in the treatment arm (combined with vitamin C) - results of individual treatments may vary.
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10/9	Review	Derosa et al., Phytotherapy Research, doi:10.1002/ptr.6887 (Review) (Peer Reviewed)	review	A role for quercetin in coronavirus disease 2019 (COVID-19)
	Details Review noting that quercetin has a theoretical, but significant, capability to interfere with SARS‐CoV‐2 replication, with results showing this to be the fifth best compound out of 18 candidates.
10/9	Details Source PDF Review Review
	Derosa et al., Phytotherapy Research, doi:10.1002/ptr.6887 (Review) (Peer Reviewed)
	A role for quercetin in coronavirus disease 2019 (COVID-19)
	Review noting that quercetin has a theoretical, but significant, capability to interfere with SARS‐CoV‐2 replication, with results showing this to be the fifth best compound out of 18 candidates. Derosa et al., 10/9/2020, peer-reviewed, 4 authors.
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6/19	Review	Biancatelli et al., Frontiers in Immunology, doi:10.3389/fimmu.2020.01451 (Review) (Peer Reviewed)	review	Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)
	Details Review of the evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients.
6/19	Details Source PDF Review Review
	Biancatelli et al., Frontiers in Immunology, doi:10.3389/fimmu.2020.01451 (Review) (Peer Reviewed)
	Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)
	Review of the evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients. Biancatelli et al., 6/19/2020, peer-reviewed, 4 authors.
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