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  Submit FeedbackFeedback Pierro (RCT)86%0.14 [0.01-2.72]death0/763/76Improvement, RR [CI]TreatmentControlDi Pierro (RCT)67%0.33 [0.01-7.74]death0/211/21Tau​2 = 0.00; I​2 = 0.0%Early treatment79%0.21 [0.02-1.82]0/974/9779% improvementArslan (RCT)92%0.08 [0.01-0.79]cases1/719/42CT​1Improvement, RR [CI]TreatmentControlTau​2 = 0.00; I​2 = 0.0%PrEP92%0.08 [0.01-0.79]1/719/4292% improvementAll studies87%0.13 [0.03-0.57]1/16813/13987% improvement3 quercetin COVID-19 7/24/211 CT: study uses combined treatmentTau​2 = 0.00; I​2 = 0.0%; Z = 2.72 (p = 0.0033)Effect extraction pre-specifiedLower RiskIncreased Risk
Early Di Pierro et al., International Journal of General Medicine, doi:10.2147/IJGM.S318949 (Peer Reviewed) death, ↓66.7%, p=1.00 Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial
Details   RCT 42 outpatients in Pakistan, 21 treated with quercetin phytosome, showing faster viral clearance and lower symptom severity with treatment.
Early Di Pierro et al., International Journal of General Medicine, doi:10.2147/IJGM.S318720 (Peer Reviewed) death, ↓85.7%, p=0.25 Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study
Details   RCT 152 outpatients in Pakistan, 76 treated with quercetin phytosome, showing lower mortality, ICU admission, and hospitalization with treatment.
PrEP Arslan et al., SSRN, doi:10.2139/ssrn.3682517 (Preprint) cases, ↓91.7%, p=0.03 Synergistic Effect of Quercetin and Vitamin C Against COVID-19: Is a Possible Guard for Front Liners
Details   Small prophylaxis RCT with 113 patients showing fewer cases with quercetin+vitamin C prophylaxis. NCT04377789.
Review Derosa et al., Phytotherapy Research, doi:10.1002/ptr.6887 (Review) (Peer Reviewed) review A role for quercetin in coronavirus disease 2019 (COVID-19)
Details   Review noting that quercetin has a theoretical, but significant, capability to interfere with SARS‐CoV‐2 replication, with results showing this to be the fifth best compound out of 18 candidates.
Review Biancatelli et al., Frontiers in Immunology, doi:10.3389/fimmu.2020.01451 (Review) (Peer Reviewed) review Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)
Details   Review of the evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients.
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