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Home   COVID-19 treatment studies for Quercetin  COVID-19 treatment studies for Quercetin  C19 studies: Quercetin  Quercetin   Select treatmentSelect treatmentTreatmentsTreatments
Aspirin Molnupiravir
Bamlanivimab Nigella Sativa
Bromhexine Nitazoxanide
Budesonide Povidone-Iod..
Casirivimab/i.. Probiotics
Colchicine Proxalutamide
Conv. Plasma Quercetin
Curcumin Remdesivir
Favipiravir Sotrovimab
Fluvoxamine Vitamin A
Hydroxychloro.. Vitamin C
Iota-carragee.. Vitamin D
Ivermectin Zinc
Melatonin

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00.250.50.7511.251.51.752+Di Pierro (RCT)86%0.14 [0.01-2.72]death0/763/76Improvement, RR [CI]TreatmentControlDi Pierro (RCT)67%0.33 [0.01-7.74]death0/211/21Tau​2 = 0.00; I​2 = 0.0%Early treatment79%0.21 [0.02-1.82]0/974/9779% improvementOnal (RCT)24%0.76 [0.10-5.81]death1/5210/395CT​1Improvement, RR [CI]TreatmentControlTau​2 = 0.00; I​2 = 0.0%Late treatment24%0.76 [0.10-5.81]1/5210/39524% improvementArslan (RCT)92%0.08 [0.01-0.79]cases1/719/42CT​1Improvement, RR [CI]TreatmentControlTau​2 = 0.00; I​2 = 0.0%PrEP92%0.08 [0.01-0.79]1/719/4292% improvementAll studies76%0.24 [0.07-0.79]2/22023/53476% improvement4 quercetin COVID-19 studiesc19quercetin.com Sep 18, 20211 CT: study uses combined treatmentTau​2 = 0.00; I​2 = 0.0%; Z = 2.35Effect extraction pre-specifiedFavors quercetinFavors control
Database of all quercetin COVID-19 studies. Submit updates/corrections.
Jul 6
PrEP Margolin et al., Journal of Evidence-Based Integrative Medicine, doi:10.1177/2515690X211026193 (Peer Reviewed) cases, ↓94.4%, p=0.003 20-Week Study of Clinical Outcomes of Over-the-Counter COVID-19 Prophylaxis and Treatment
Details   Retrospective 113 outpatients, 53 (patient choice) treated with zinc, quercetin, vitamin C/D/E, l-lysine, and Quina, showing lower cases with treatment.
Jun 24
Early Di Pierro et al., International Journal of General Medicine, doi:10.2147/IJGM.S318949 (Peer Reviewed) death, ↓66.7%, p=1.00 Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial
Details   RCT 42 outpatients in Pakistan, 21 treated with quercetin phytosome, showing faster viral clearance and lower symptom severity with treatment.
Jun 8
Early Di Pierro et al., International Journal of General Medicine, doi:10.2147/IJGM.S318720 (Peer Reviewed) death, ↓85.7%, p=0.25 Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study
Details   RCT 152 outpatients in Pakistan, 76 treated with quercetin phytosome, showing lower mortality, ICU admission, and hospitalization with treatment.
Apr 8
Early Aguilar et al., Journal of Advances in Medical and Pharmaceutical Sciences, doi:10.9734/jamps/2021/v23i330222 (Peer Reviewed) Oral Quercetin in Adult Patients as a Potential Nutraceutical against Coronavirus Disease 2019 (COVID-19)
Details   Prospective study of 52 patients treated with quercetin. There was no control group.
Jan 19
Late Onal et al., Authorea, doi:10.22541/au.161106492.28349832/v1 (Preprint) death, ↓24.0%, p=1.00 Treatment of COVID-19 Patients with Quercetin: A Prospective, Single - Centre, Randomized, Controlled Trial
Details   RCT 447 moderate-to-severe hospitalized patients in Turkey, 52 treated with quercetin, bromelain, and vitamin C, showing no statistically significant difference in clinical outcomes. NCT04377789.
Nov 16
2020
PrEP Arslan et al., SSRN, doi:10.2139/ssrn.3682517 (Preprint) cases, ↓91.7%, p=0.03 Synergistic Effect of Quercetin and Vitamin C Against COVID-19: Is a Possible Guard for Front Liners
Details   Small prophylaxis RCT with 113 patients showing fewer cases with quercetin + vitamin C + bromelain prophylaxis. NCT04377789. Note that this paper disappeared from SSRN without explanation.
Oct 9
2020
Review Derosa et al., Phytotherapy Research, doi:10.1002/ptr.6887 (Review) (Peer Reviewed) review A role for quercetin in coronavirus disease 2019 (COVID-19)
Details   Review noting that quercetin has a theoretical, but significant, capability to interfere with SARS‐CoV‐2 replication, with results showing this to be the fifth best compound out of 18 candidates.
Jun 19
2020
Review Biancatelli et al., Frontiers in Immunology, doi:10.3389/fimmu.2020.01451 (Review) (Peer Reviewed) review Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)
Details   Review of the evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients.
Apr 24
2020
In Silico Sekiou et al., ChemRxiv, doi:10.26434/chemrxiv.12181404.v1 (Preprint) In-Silico Identification of Potent Inhibitors of COVID-19 Main Protease (Mpro) and Angiotensin Converting Enzyme 2 (ACE2) from Natural Products: Quercetin, Hispidulin, and Cirsimaritin Exhibited Better Potential Inhibition than Hydroxy-Chloroquine Against COVID-19 Main Protease Active Site and ACE2
Details   In silico study of natural compounds identifying quercetin, curcumin, hispidulin, cirsimaritin, sulfasalazine, and artemisin as potential compounds that inhibit SARS-CoV-2.
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